Silver triflate and triflic anhydride-promoted expedient synthesis of acylated 1-aminoisoquinolines.
نویسندگان
چکیده
A practical and convergent synthesis of biologically active 1-(N-acyl)-1-aminoisoquinolines from the reaction of 2-alkynylbenzaldoximes with amides has been realized. The readily available amides could be activated with triflic anhydride (Tf2O) and could efficiently participate in the domino reaction of 2-alkynylbenzaldoximes when catalyzed by AgOTf, thus providing various acylated 1-aminoisoquinolines with up to 98% yields.
منابع مشابه
An efficient route to 1-aminoisoquinolines via AgOTf-catalyzed reaction of 2-alkynylbenzaldoxime with amine.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 12 36 شماره
صفحات -
تاریخ انتشار 2014